Supported Applications


  • Description

    SINA aligns nucleotide sequences to match a pre-existing MSA using a graph based alignment algorithm similar to PoA. The graph approach allows SINA to incorporate information from many reference sequences building without blurring highly variable regions. While pure NAST implementations depend highly on finding a good match in the reference database, SINA is able to align sequences relatively distant to references with good quality and will yield a robust result for query sequences with many close reference.

  • Installation

    Use the following command to install this title with the CLI client: $ biogrids-cli install sina Copy to clipboard
  • Primary Citation*

    E. Pruesse, J. Peplies, and G. FO.. 2012. SINA: accurate high-throughput multiple sequence alignment of ribosomal RNA genes. Bioinformatics. 28(14): 1823-1829.

    • *Full citation information available through