Supported Applications

hapLOHseq

  • Description

    Developed for the detection of subtle allelic imbalance events from next-generation sequencing data, hapLOHseq is a sequencing-based extension of hapLOH, which is a method for the detection of subtle allelic imbalance events from SNP array data. It is capable of identifying events of 10 mega-bases or greater occurring in as little as 16% of the sample using exome sequencing data (at 80x) and 4% using whole genome se-quencing data (at 30x), exceeding the capabilities of existing software.

  • Primary Citation*

    F. A. S. Lucas, S. Sivakumar, S. Vattathil, J. Fowler, E. Vilar, and S. P.. 2016. Rapid and powerful detection of subtle allelic imbalance from exome sequencing data with hapLOHseq. Bioinformatics.. 32(19): 3015-3017.


    • *Full citation information available through

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