Supported Applications
MR-MEGA
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Description
( Meta-Regression of Multi-AncEstry Genetic Association ) is a specialized statistical tool designed for the meta-analysis of multi-ethnic genome-wide association studies (GWAS). Developed by the Reed Group at the University of Tartu, it utilizes a trans-ethnic approach to identify shared genetic effects across diverse populations while accounting for heterogeneity in allelic effects and ancestry. By incorporating principal component analysis to model ancestry-specific effect sizes, MR-MEGA enables researchers to increase discovery power and refine the fine-mapping of causal variants in globally diverse cohorts.
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Primary Citation*
R. Mägi, M. Horikoshi, T. Sofer, A. Mahajan, H. Kitajima, N. Franceschini, M. I. McCarthy, C.-K. Consortium, T.-G. Consortium, and A. P. Morris. 2017. Trans-ethnic meta-regression of genome-wide association studies accounting for ancestry increases power for discovery and improves fine-mapping resolution. Human molecular genetics. 26(18): 3639-3650.
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*Full citation information available through
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Keywords
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Default Versions
Linux 64: 0.2 (410.7 KB)
OS X INTEL: 0.2 (348.7 KB)