Member Publications

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145 Member Publications for March 2025

Tolerance of Placozoa for temperate climates: Evidence for known and new placozoan clades in the southern waters of Australia.
1. PLoS One - published March 19, 2025
2. Wright BA, Osigus HJ, Schmidt MJ, Ratcliffe J, Kamm K, Martinez-Ortiz GC, Rehn M, Kvansakul M, Schierwater B, Humbert PO
Proteasome dynamics in response to metabolic changes.
1. Front Cell Dev Biol - published March 18, 2025
2. Enenkel C, Ernst OP
Molecular model of TFIIH recruitment to the transcription-coupled repair machinery.
1. Nat Commun - published March 8, 2025
2. Paul T, Yan C, Yu J, Tsutakawa SE, Tainer JA, Wang D, Ivanov I
G-quadruplex-stalled eukaryotic replisome structure reveals helical inchworm DNA translocation.
1. Science - published March 7, 2025
2. Batra S, Allwein B, Kumar C, Devbhandari S, Brüning JG, Bahng S, Lee CM, Marians KJ, Hite RK, Remus D
Hierarchical Assembly of Conductive Fibers from Coiled-Coil Peptide Building Blocks.
1. ACS Nano - published March 7, 2025
2. Grosvirt-Dramen A, Urbach ZJ, Hurst PJ, Kwok CE, Patterson JP, Wang F, Hochbaum AI
Crystal structures of monomeric BsmI restriction endonuclease reveal coordinated sequential cleavage of two DNA strands.
1. Commun Biol - published March 7, 2025
2. Sieskind R, Missoury S, Madru C, Commenge I, Niogret G, Hollenstein M, Rondelez Y, Sauguet L, Haouz A, Legrand P, Delarue M
A potent and selective TNKS2 inhibitor for tumor-selective WNT suppression.
1. bioRxiv - published March 7, 2025
2. Zimmerman J, Malone BF, Finkin-Groner E, Sun S, Liang R, Foronda M, Schatoff EM, Granowsky E, Goswami S, Katti A, Leach B, Alcorn H, Tammela T, Fukase Y, Khan T, Huggins DJ, Ginn J, Liverton N, Hite RK, Dow LE
Shifting the PPARγ conformational ensemble towards a transcriptionally repressive state improves covalent inhibitor efficacy.
1. bioRxiv - published March 7, 2025
2. Arifova L, MacTavish BS, Laughlin Z, Giridhar MNK, Shang J, Li MH, Yu X, Zhu D, Kamenecka TM, Kojetin DJ
Zα and Zβ Localize ADAR1 to Flipons That Modulate Innate Immunity, Alternative Splicing, and Nonsynonymous RNA Editing.
1. Int J Mol Sci - published March 7, 2025
2. Herbert A, Cherednichenko O, Lybrand TP, Egli M, Poptsova M
Energy filtering enables macromolecular MicroED data at sub-atomic resolution.
1. Nat Commun - published March 6, 2025
2. Clabbers MTB, Hattne J, Martynowycz MW, Gonen T
On the role of VP3-PI3P interaction in birnavirus endosomal membrane targeting.
1. Elife - published March 6, 2025
2. Zanetti FA, Fernandez I, Baquero E, Guardado-Calvo P, Ferrino-Iriarte A, Dubois S, Morel E, Alfonso V, Aguilera MO, Celayes ME, Polo LM, Suhaiman L, Galassi VV, Chiarpotti MV, Allende-Ballestero C, Rodriguez JM, Castón JR, Lijavetzky D, Taboga O, Colombo MI, Del Pópolo M, Rey FA, Delgui LR
Impacts of ribosomal RNA sequence variation on gene expression and phenotype.
1. Philos Trans R Soc Lond B Biol Sci - published March 6, 2025
2. Welfer GA, Brady RA, Natchiar SK, Watson ZL, Rundlet EJ, Alejo JL, Singh AP, Mishra NK, Altman RB, Blanchard SC
Pseudo-ring methodology to control the conformations of macrocycles.
1. Chemistry - published March 6, 2025
2. Diamandas M, Ou D, Huang B, Yudin AK
Mammalian TMC1 or 2 are necessary for scramblase activity in auditory hair cells.
1. Hear Res - published March 6, 2025
2. Peineau T, Marcovich I, Rodriguez CVM, O'Malley S, Cui R, Ballesteros A, Holt JR
Deconvolution to restore cryo-EM maps with anisotropic resolution.
1. Res Sq - published March 6, 2025
2. Cheng Y, Li J, Chen Y, Zheng S, McDonald A, Sedat J, Agard D
Phenotypic pleiotropy of missense variants in human B cell-confinement receptor P2RY8.
1. bioRxiv - published March 6, 2025
2. LaFlam TN, Billesbølle CB, Dinh T, Wolfreys FD, Lu E, Matteson T, An J, Xu Y, Singhal A, Brandes N, Ntranos V, Manglik A, Cyster JG, Ye CJ
Broadly neutralizing antibodies targeting pandemic GII.4 variants or seven GII genotypes of human norovirus.
1. Sci Transl Med - published March 5, 2025
2. Park J, Lindesmith LC, Olia AS, Costantini VP, Brewer-Jensen PD, Mallory ML, Kelley CE, Satterwhite E, Longo V, Tsybovsky Y, Stephens T, Marchioni J, Martins CA, Huang Y, Chaudhary R, Zweigart M, May SR, Reyes Y, Flitter B, Vinjé J, Tucker SN, Ippolito GC, Lavinder JJ, Snijder J, Kwong PD, Georgiou G, Baric RS
Bispecific antibodies targeting the N-terminal and receptor binding domains potently neutralize SARS-CoV-2 variants of concern.
1. Sci Transl Med - published March 5, 2025
2. Rubio AA, Baharani VA, Dadonaite B, Parada M, Abernathy ME, Wang Z, Lee YE, Eso MR, Phung J, Ramos I, Chen T, El Nesr G, Bloom JD, Bieniasz PD, Nussenzweig MC, Barnes CO
New insights into the noncanonical inflammasome point to caspase-4 as a druggable target.
1. Nat Rev Immunol - published March 5, 2025
2. Elkayam E, Gervais FG, Wu H, Crackower MA, Lieberman J
Improving CryoEM maps of symmetry-mismatched macromolecular assemblies: A case study on the flagellar motor.
1. J Struct Biol - published March 5, 2025
2. Singh PK, Iverson TM
MicroED Structures of Fluticasone Furoate and Fluticasone Propionate Provide New Insights into Their Function.
1. Cryst Growth Des - published March 5, 2025
2. Lin J, Unge J, Gonen T
Exportin-1 functions as an adaptor for transcription factor-mediated docking of chromatin at the nuclear pore complex.
1. Mol Cell - published March 5, 2025
2. Ge T, Brickner DG, Zehr K, VanBelzen DJ, Zhang W, Caffalette C, Moeller GC, Ungerleider S, Marcou N, Jacob A, Nguyen VQ, Chait B, Rout MP, Brickner JH
Bipartite binding of the intrinsically disordered scaffold protein JIP1 to the kinase JNK1.
1. Proc Natl Acad Sci U S A - published March 4, 2025
2. Orand T, Delaforge E, Lee A, Kragelj J, Tengo M, Tengo L, Blackledge M, Boeri Erba E, Davis RJ, Palencia A, Jensen MR
CODANIN-1 sequesters ASF1 by using a histone H3 mimic helix to regulate the histone supply.
1. Nat Commun - published March 4, 2025
2. Jeong TK, Frater RCM, Yoon J, Groth A, Song JJ
Multifunctional Hydrogel Electrolyte Synergizing with Free-Standing Cathode Enables Robust Aqueous Zinc Metal Batteries.
1. Small - published March 4, 2025
2. Gong P, Zhai S, Liu S, Chai S, Wang N, Li Y, Liu J
Covalent inhibition of the SARS-CoV-2 NiRAN domain via an active-site cysteine.
1. J Biol Chem - published March 4, 2025
2. Hernandez G, Osinski A, Majumdar A, Eitson JL, Antczak M, Pawłowski K, Niederstrasser H, Servage KA, Posner B, Schoggins JW, Ready JM, Tagliabracci VS
Rational design of gold nanoparticle-based chemosensors for detection of the tumor marker 3-methoxytyramine.
1. Chem Sci - published March 4, 2025
2. Franco-Ulloa S, Cesari A, Zanoni G, Riccardi L, Wallace J, Mascitti BB, Rastrelli F, Mancin F, De Vivo M
Novel Roles of Nestin in Postnatal Root Formation.
1. Dent J (Basel) - published March 4, 2025
2. Jing Y, Wu J, Liu Y, Liu X, Ma C
α-Catenin force-sensitive binding and sequestration of LZTS2 leads to cytokinesis failure.
1. J Cell Biol - published March 3, 2025
2. Wang Y, Yemelyanov A, Go CD, Kim SK, Quinn JM, Flozak AS, Le PM, Liang S, Gingras AC, Ikura M, Ishiyama N, Gottardi CJ
Electrostatics of salt-dependent reentrant phase behaviors highlights diverse roles of ATP in biomolecular condensates.
1. Elife - published March 3, 2025
2. Lin YH, Kim TH, Das S, Pal T, Wessén J, Rangadurai AK, Kay LE, Forman-Kay JD, Chan HS
Multiomic spatial atlas shows deleted in malignant brain tumors 1 (DMBT1) glycoprotein is lost in colonic dysplasia.
1. J Pathol - published March 3, 2025
2. Green EH, Kotrannavar SR, Rutherford ME, Lunnemann HM, Kaur H, Heiser CN, Ding H, Simmons AJ, Liu X, Lacy DB, Washington MK, Shrubsole MJ, Liu Q, Lau KS, Sears CL, Coffey RJ, Drewes JL, Markham NO
Beyond First-Generation KRAS Inhibitors: BBO-8520 Tests the Dual Mechanism Hypothesis.
1. Cancer Discov - published March 3, 2025
2. Zhou Z, Westover KD
Members of the DIP and Dpr adhesion protein families use cis inhibition to shape neural development in Drosophila.
1. PLoS Biol - published March 3, 2025
2. Morano NC, Lopez DH, Meltzer H, Sergeeva AP, Katsamba PS, Rostam KD, Gupta HP, Becker JE, Bornstein B, Cosmanescu F, Schuldiner O, Honig B, Mann RS, Shapiro L
Lipid Dysregulation in Tangier Disease: A Case Series and Metabolic Characterization.
1. J Clin Endocrinol Metab - published March 3, 2025
2. Semmler G, Baumgartner C, Metz M, Gensluckner S, Habisch H, Hofer H, März W, Offner F, Völkerer A, Petrenko O, Wernly B, Draxler-Dworzak S, Neyer M, Nigmann C, Greber-Platzer S, Esterbauer H, Madl T, Aigner E, Scherer T, Datz C
In-Cell Fast Photochemical Oxidation Interrogates the Native Structure of Integral Membrane Proteins.
1. Angew Chem Int Ed Engl - published March 3, 2025
2. Sun J, Saimi M, Rempel D, Cao Q, Chang ML, Li W, Gross ML
FakeRotLib: expedient non-canonical amino acid parameterization in Rosetta.
1. bioRxiv - published March 3, 2025
2. Bell EW, Brown BP, Meiler J
Structural basis of ClC-3 inhibition by TMEM9 and PI(3,5)P(2).
1. bioRxiv - published March 3, 2025
2. Schrecker M, Son Y, Planells-Cases R, Kar S, Vorobeva V, Schulte U, Fakler B, Jentsch TJ, Hite RK
Sharing data from the Human Tumor Atlas Network through standards, infrastructure and community engagement.
1. Nat Methods - published March 3, 2025
2. de Bruijn I, Nikolov M, Lau C, Clayton A, Gibbs DL, Mitraka E, Pozhidayeva D, Lash A, Sumer SO, Altreuter J, Anton K, DeFelice M, Li X, Lisman A, Longabaugh WJR, Muhlich J, Santagata S, Nandakumar S, Sorger PK, Suver C, Doan X, Guinney J, Schultz N, Taylor AJ, Thorsson V, Cerami E, Eddy JA
Enhanced RNA replication and pathogenesis in recent SARS-CoV-2 variants harboring the L260F mutation in NSP6.
1. PLoS Pathog - published March 3, 2025
2. Taha TY, Ezzatpour S, Hayashi JM, Ye C, Zapatero-Belinchón FJ, Rosecrans JA, Kimmerly GR, Chen IP, Walcott K, Kurianowicz A, Jorgens DM, Chaplin NR, Choi A, Buchholz DW, Sahler J, Hilt ZT, Imbiakha B, Vagi-Szmola C, Montano M, Stevenson E, Gordon M, Swaney DL, Krogan NJ, Whittaker GR, Martinez-Sobrido L, Aguilar HC, Ott M
Adenosine deaminase and deoxyadenosine regulate intracellular immune response in C. elegans.
1. iScience - published March 2, 2025
2. Wernet ND, Tecle E, Sarmiento MB, Kuo CJ, Chhan CB, Baick I, Batachari LE, Franklin L, Herneisen A, Bhabha G, Ekiert DC, Hanna-Rose W, Troemel ER
Repulsive interactions instruct synaptic partner matching in an olfactory circuit.
1. bioRxiv - published March 2, 2025
2. Li Z, Lyu C, Xu C, Hu Y, Luginbuhl DJ, Caspi-Lebovic AB, Priest JM, Özkan E, Luo L
Flycodes enable simultaneous preclinical analysis for dozens of antibodies in single cassette-dosed mice.
1. Proc Natl Acad Sci U S A - published March 2, 2025
2. Walter JD, Beffinger M, Egloff P, Zimmermann I, Hürlimann LM, Ackle F, Seifert M, Kobold S, Vom Berg J, Seeger MA
Staphylococcus aureus uses a GGDEF protein to recruit diacylglycerol kinase to the membrane for lipid recycling.
1. Proc Natl Acad Sci U S A - published March 2, 2025
2. Mychack A, Evans D, Gilles T, James MJ, Walker S
Phi29 assembly intermediates reveal how scaffold interactions with capsid protein drive capsid construction and maturation.
1. Sci Adv - published March 2, 2025
2. Woodson M, Prokhorov NS, Scott SD, Zhao W, Zhang W, Choi KH, Jardine PJ, Morais MC
Lactate dehydrogenase is the Achilles' heel of Lyme disease bacterium Borreliella burgdorferi.
1. mBio - published March 2, 2025
2. Sze CW, Lynch MJ, Zhang K, Neau DB, Ealick SE, Crane BR, Li C
Corrigendum to "IgA class switching enhances neutralizing potency against SARS-CoV-2 by increased antibody hinge flexibility" [Antiv. Res. (2025) 106082].
1. Antiviral Res - published March 2, 2025
2. Xu M, Zhang Z, Sun Y, Mai H, Liu S, Liu S, Lv K, Yu F, Wang Y, Yue X, Zhang J, Cai X, Zhao R, Lu H, Liu L, Luo H, Zhao H, Wang Y, Gong P, Chen S, Jing X, Zhao J, Chen YQ
SnapShot: Human sperm-egg interface proteins.
1. Cell - published March 2, 2025
2. Forster E, Wang X, Thayaparan A, Lee JE
Transport and InsP(8) gating mechanisms of the human inorganic phosphate exporter XPR1.
1. Nat Commun - published March 2, 2025
2. Zhu Q, Yaggi MF, Jork N, Jessen HJ, Diver MM
Synthesis of Differentially Halogenated Lissoclimide Analogues To Probe Ribosome E-Site Binding.
1. ACS Chem Biol - published March 2, 2025
2. Terrosu S, Nurullina L, Supantanapong N, Pak BS, Nguyen S, Holm M, Wu C, Lin M, Horne D, Sachs MS, Blanchard SC, Yusupov M, Vanderwal CD
Publisher Correction: Energy filtering enables macromolecular MicroED data at sub-atomic resolution.
1. Nat Commun - published March 2, 2025
2. Clabbers MTB, Hattne J, Martynowycz MW, Gonen T
Structural and functional analysis of Pseudomonas aeruginosa PelA provides insight into the modification of the Pel exopolysaccharide.
1. J Biol Chem - published March 2, 2025
2. Van Loon JC, Le Mauff F, Vargas MA, Gilbert S, Pfoh R, Morrison ZA, Razvi E, Nitz M, Sheppard DC, Howell PL
An Efficient Lysate-Based Approach for Biosynthesis of the Pyrrolobenzodiazepine Natural Product Tilimycin.
1. J Biotechnol - published March 2, 2025
2. MacDonald MR, Gulick AM
In Situ Light-driven pH Modulation for NMR Studies.
1. Angew Chem Int Ed Engl - published March 2, 2025
2. Barde A, Han R, Olson MA, Tonelli M, Rienstra CM, Henzler-Wildman KA, Ravula T
Structural insight into the cGAS active site explains differences between therapeutically relevant species.
1. Commun Chem - published March 2, 2025
2. Skeldon AM, Wang L, Sgarioto N, Beveridge RE, Chan S, Dorich S, Dumais V, Fradet N, Gaudreault S, LeGros P, McKay D, Seliniotakis R, Sietsema DV, Zhang L, Boily MO, Burch JD, Caron A, Fader LD, Lama L, Xie W, Patel DJ, Tuschl T, Crackower MA, Pike KA
A synthetic opsin restores vision in patients with severe retinal degeneration.
1. Mol Ther - published March 2, 2025
2. Mohanty SK, Mahapatra S, Batabyal S, Carlson M, Kanungo G, Ayyagari A, Tchedre K, Franco JA, Singer M, Barone S, Chavala S, Mahajan VB
Structural Mechanisms of Topoisomerase-Targeting Drugs.
1. Annu Rev Biochem - published March 2, 2025
2. O'Donnell AC, Berger JM
Structure and cooperative formation of a FLI1 filament on contiguous GGAA DNA sites.
1. Nucleic Acids Res - published March 2, 2025
2. Hou C, Tsodikov OV
Molecular basis for human respiratory syncytial virus transcriptional regulator NS1 interactions with MED25.
1. Nat Commun - published March 2, 2025
2. Kalita P, Khatavkar O, Uwase G, Korshunova Y, Hu Y, Wagner ND, Xu J, Pan J, Nix JC, Gross ML, Brody SL, Borek D, Amarasinghe GK, Payton JE, Leung DW
MFSD6 is an entry receptor for enterovirus D68.
1. Nature - published March 2, 2025
2. Varanese L, Xu L, Peters CE, Pintilie G, Roberts DS, Raj S, Liu M, Ooi YS, Diep J, Qiao W, Richards CM, Callaway J, Bertozzi CR, Jabs S, de Vries E, van Kuppeveld FJM, Nagamine CM, Chiu W, Carette JE
Functional and antigenic landscape of the Nipah virus receptor-binding protein.
1. Cell - published March 2, 2025
2. Larsen BB, McMahon T, Brown JT, Wang Z, Radford CE, Crowe JE Jr, Veesler D, Bloom JD
Identification of functional rare coding variants in IGF-1 gene in humans with exceptional longevity.
1. Sci Rep - published March 2, 2025
2. Ali A, Zhang ZD, Gao T, Aleksic S, Gavathiotis E, Barzilai N, Milman S
About proteins of a siphophage tail tip complex reverting to their pre-ejection fold after DNA ejection.
1. Nat Commun - published March 2, 2025
2. Arnaud CA, Linares R, Rossier O, Boeri Erba E, Boulanger P, Schoehn G, Breyton C
Reply to: About proteins of a siphophage tail tip complex reverting to their pre-ejection fold after DNA ejection.
1. Nat Commun - published March 2, 2025
2. Ayala R, Moiseenko AV, Chen TH, Kulikov EE, Golomidova AK, Orekhov PS, Street MA, Sokolova OS, Letarov AV, Wolf M
Ligand Screening and Discovery Using Cocktail Soaking and Automated Microcrystal Electron Diffraction.
1. ChemMedChem - published March 2, 2025
2. Lin J, Gallenito MJ, Hattne J, Gonen T
Leucine aminopeptidase LyLAP enables lysosomal degradation of membrane proteins.
1. Science - published March 2, 2025
2. Jain A, Heremans I, Rademaker G, Detomasi TC, Rohweder P, Anderson D, Zhang J, Hernandez GA, Gupta S, von Linde T, Lange M, Spacci M, Luo J, Citron YR, Olzmann JA, Dawson DW, Craik CS, Bommer G, Perera RM, Zoncu R
Eph receptors activate myeloid checkpoint receptor LILRB5 to support tumor development.
1. Cancer Immunol Res - published March 2, 2025
2. He Y, Zhang C, Tan L, Deng M, Liu X, Huang R, Yang X, Xie J, Lou Q, Fang M, Smith C, John S, Xiong W, Li X, Lewis C, Homsi J, Gupta A, Zhang N, An Z, Zhang C
Lecithin:Cholesterol Acyltransferase Binds a Discontinuous Binding Site on Adjacent Apolipoprotein A-I Belts in HDL.
1. J Lipid Res - published March 2, 2025
2. Coleman B, Bedi S, Hill JH, Morris J, Manthei KA, Hart RC, He Y, Shah AS, Jerome WG, Vaisar T, Bornfeldt KE, Song H, Segrest JP, Heinecke JW, Aller SG, Tesmer JJG, Davidson WS
A coronavirus assembly inhibitor that targets the viral membrane protein.
1. Nature - published March 2, 2025
2. Laporte M, Jochmans D, Bardiot D, Desmarets L, Debski-Antoniak OJ, Mizzon G, Abdelnabi R, Leyssen P, Chiu W, Zhang Z, Nomura N, Boland S, Ohto U, Stahl Y, Wuyts J, De Jonghe S, Stevaert A, van Hemert MJ, Bontes BW, Wanningen P, Groenewold GJM, Zegar A, Owczarek K, Joshi S, Koukni M, Arzel P, Klaassen H, Vanherck JC, Vandecaetsbeek I, Cremers N, Donckers K, Francken T, Van Buyten T, Rymenants J, Schepers J, Pyrc K, Hilgenfeld R, Dubuisson J, Bosch BJ, Van Kuppeveld F, Eydoux C, Decroly E, Canard B, Naesens L, Weynand B, Snijder EJ, Belouzard S, Shimizu T, Bartenschlager R, Hurdiss DL, Marchand A, Chaltin P, Neyts J
Structure of the lens MP20 mediated adhesive junction.
1. Nat Commun - published March 2, 2025
2. Nicolas WJ, Shiriaeva A, Martynowycz MW, Grey AC, Ruma YN, Donaldson PJ, Gonen T
Glutamate gating of AMPA-subtype iGluRs at physiological temperatures.
1. Nature - published March 2, 2025
2. Kumar Mondal A, Carrillo E, Jayaraman V, Twomey EC
Development and optimization of human T-cell leukemia virus-specific antibody-dependent cell-mediated cytotoxicity (ADCC) assay directed to the envelope protein.
1. J Virol - published March 2, 2025
2. Pise-Masison CA, Rahman MA, Masison DC, Gutowska A, Moles R, Bissa M, Sarkis S, Schifanella L, Zhou T, Jones J, Jacobson S, Franchini G
Circadian clock is critical for fungal pathogenesis by regulating zinc starvation response and secondary metabolism.
1. Sci Adv - published March 2, 2025
2. Lu Q, Yu M, Sun X, Zhou X, Zhang R, Zhang Y, Liu XL, Li Z, Cai L, Liu H, Li S, Dang Y, Xu X, He Q, Liu Y, Liu X
Substrates bind to residues lining the ring of asymmetrically engaged bacterial proteasome activator Bpa.
1. Nat Commun - published March 2, 2025
2. von Rosen T, Zdanowicz R, El Hadeg Y, Afanasyev P, Boehringer D, Leitner A, Glockshuber R, Weber-Ban E
Structural insights into traffic through the Golgi complex.
1. Curr Opin Cell Biol - published March 2, 2025
2. Brownfield BA, Fromme JC
Highly potent quinoxalinediones inhibit α-hemolysin and ameliorate Staphylococcus aureus lung infections.
1. Cell Host Microbe - published March 2, 2025
2. Shekhar A, Di Lucrezia R, Jerye K, Korotkov VS, Harmrolfs K, Rox K, Weich HA, Ghai I, Delhommel F, Becher I, Degenhart C, Fansa E, Unger A, Habenberger P, Klebl B, Lukat P, Schmelz S, Henke S, Borgert S, Lang JC, Sasse F, Diestel R, Richter C, Schneider-Daum N, Hinkelmann B, Niemz J, Lehr CM, Jänsch L, Huehn J, Alm R, Savitski M, Welte T, Hesterkamp T, Sattler M, Winterhalter M, Blankenfeldt W, Medina E, Bilitewski U, Dinkel K, Brönstrup M
Sequential membrane- and protein-bound organelles compartmentalize genomes during phage infection.
1. Cell Host Microbe - published March 2, 2025
2. Armbruster EG, Rani P, Lee J, Klusch N, Hutchings J, Hoffman LY, Buschkaemper H, Enustun E, Adler BA, Inlow K, VanderWal AR, Hoffman MY, Daksh D, Aindow A, Deep A, Rodriguez ZK, Morgan CJ, Ghassemian M, Laughlin TG, Charles E, Cress BF, Savage DF, Doudna JA, Pogliano K, Corbett KD, Villa E, Pogliano J
Understanding, inhibiting, and engineering membrane transporters with high-throughput mutational screens.
1. Cell Chem Biol - published March 2, 2025
2. Miller ST, Macdonald CB, Raman S
Ultrastable and versatile multimeric ensembles of FoxP3 on microsatellites.
1. Mol Cell - published March 2, 2025
2. Leng F, Merino-Urteaga R, Wang X, Zhang W, Ha T, Hur S
Modular Nanoparticle Platform for Solution-Phase Optical Sensing of Protein-Protein Interactions.
1. ACS Appl Opt Mater - published March 2, 2025
2. Zhou J, Ridderbeek K, Zou P, Naden AB, Gaussmann S, Song F, Falter-Braun P, Kay ER, Sattler M, Cui J
Altering translation allows E. coli to overcome G-quadruplex stabilizers.
1. Nucleic Acids Res - published March 2, 2025
2. Cueny RR, Voter AF, McKenzie AM, Morgenstern M, Myers KS, Place MM, Peters JM, Coon JJ, Keck JL
In vivo nucleotide excision repair by mycobacterial UvrD1 requires ATP hydrolysis but does not depend on cysteine disulfide-mediated dimerization and DNA unwinding.
1. Nucleic Acids Res - published March 2, 2025
2. Warren GM, Shuman S
SMARCB1 missense mutants disrupt SWI/SNF complex stability and remodeling activity.
1. Res Sq - published March 2, 2025
2. Cooper GW, Lee BP, Kim WJ, Su Y, Chen VZ, Salas E, Yang X, Lintner RE, Piccioni F, Giacomelli AO, Howard TP, Bagchi P, Conneely KN, Root DE, Liang B, Hahn WC, Gorkin DU, Biegel JA, Chi SN, Hong AL
A CRISPR-Cas9 System for Knock-out and Knock-in of High Molecular Weight DNA Enables Module-Swapping of the Pikromycin Synthase in its Native Host.
1. Res Sq - published March 2, 2025
2. Wang ZC, Stegall H, Miyazawa T, Keatinge-Clay AT
Recovering high-resolution information using energy filtering in MicroED.
1. bioRxiv - published March 2, 2025
2. Clabbers MTB, Gonen T
Search for improved triplet-state quenchers for fluorescence imaging: a computational framework incorporating excited-state Baird-aromaticity.
1. Chem Sci - published March 2, 2025
2. El Bakouri O, Johnson MA, Smith JR, Pati AK, Martin MI, Blanchard SC, Ottosson H
Targeting Bottlenecks in Malaria Transmission: Antibody-Epitope Descriptions Guide the Design of Next-Generation Biomedical Interventions.
1. Immunol Rev - published March 1, 2025
2. Yoo R, Jore MM, Julien JP
Crystal structure of dihydroorotate dehydrogenase from Helicobacter pylori with bound flavin mononucleotide.
1. Acta Crystallogr F Struct Biol Commun - published March 1, 2025
2. Agarwal AA, Georgiades JD, Dranow DM, Lorimer DD, Edwards T, Barrett KF, Craig JK, Van Voorhis WC, Myler PJ, Smith CL
Protein Data Bank Japan: Improved tools for sequence-oriented analysis of protein structures.
1. Protein Sci - published March 1, 2025
2. Bekker GJ, Nagao C, Shirota M, Nakamura T, Katayama T, Kihara D, Kinoshita K, Kurisu G
Torsional twist of the SARS-CoV and SARS-CoV-2 SUD-N and SUD-M domains.
1. Protein Sci - published March 1, 2025
2. Rosas-Lemus M, Minasov G, Brunzelle JS, Taha TY, Lemak S, Yin S, Shuvalova L, Rosecrans J, Khanna K, Seifert HS, Savchenko A, Stogios PJ, Ott M, Satchell KJF
Architects of infection: A structural overview of SARS-related coronavirus spike glycoproteins.
1. Virology - published March 1, 2025
2. Hills FR, Geoghegan JL, Bostina M
Allium Macrostemon Bge. Attenuates the Cognitive Decline of Aging Mice by Enhancing BDNF/TrkB Pathway.
1. Food Sci Nutr - published March 1, 2025
2. Sheng R, Zhao M, Pu K, Zhou Y, Zeng L, Chen Y, Wang P, Liu X, Xu S
Coronavirus endoribonuclease antagonizes ZBP1-mediated necroptosis and delays multiple cell death pathways.
1. Proc Natl Acad Sci U S A - published March 1, 2025
2. Evdokimova M, Feng S, Caobi A, Moreira FR, Jones D, Alysandratos KD, Tully ES, Kotton DN, Boyd DF, Banach BS, Kirchdoerfer RN, Saeed M, Baker SC
Allosteric inhibition of the IZUMO1-JUNO fertilization complex by the naturally occurring antisperm antibody OBF13.
1. Proc Natl Acad Sci U S A - published March 1, 2025
2. Lu Y, Ikawa M, Tang S
Parallelized Tools for the Preparation and Curation of Large Libraries for Virtual Screening.
1. J Comput Chem - published March 1, 2025
2. Vitalis A, Parker D, Radler F, Vargas-Rosales PA, Zhang Y, Marchand JR, Caflisch A
Expression and Purification of SARS-related Spike Glycoproteins for Cryo-EM Analysis.
1. Curr Protoc - published March 1, 2025
2. Hills FR, Jorge F, Burga LN, Bostina M
A bivalent spike-targeting nanobody with anti-sarbecovirus activity.
1. J Nanobiotechnology - published March 1, 2025
2. Swart IC, Debski-Antoniak OJ, Zegar A, de Bouter T, Chatziandreou M, van den Berg M, Drulyte I, Pyrć K, de Haan CAM, Hurdiss DL, Bosch BJ, Oliveira S
Protein interactions, calcium, phosphorylation, and cholesterol modulate CFTR cluster formation on membranes.
1. Proc Natl Acad Sci U S A - published March 1, 2025
2. Wan Y, Hudson R, Smith J, Forman-Kay JD, Ditlev JA
Metagenomic selections reveal diverse antiphage defenses in human and environmental microbiomes.
1. bioRxiv - published March 1, 2025
2. Rodriguez-Rodriguez L, Pfister J, Schuck L, Martin AE, Mercado-Santiago LM, Tagliabracci VS, Forsberg KJ
Deconvolution to restore cryo-EM maps with anisotropic resolution.
1. bioRxiv - published March 1, 2025
2. Li J, Chen Y, Zheng S, McDonald A, Sedat JW, Agard DA, Cheng Y
Complex water networks visualized by cryogenic electron microscopy of RNA.
1. Nature - published March 1, 2025
2. Kretsch RC, Li S, Pintilie G, Palo MZ, Case DA, Das R, Zhang K, Chiu W
Epitope-directed selection of GPCR nanobody ligands with evolvable function.
1. Proc Natl Acad Sci U S A - published March 1, 2025
2. Skiba MA, Canavan C, Nemeth GR, Liu J, Kanso A, Kruse AC
Lipid Dynamics at Membrane Contact Sites.
1. Annu Rev Biochem - published March 1, 2025
2. Reinisch KM, De Camilli P, Melia TJ
Cryo-ET reveals the in situ architecture of the polar tube invasion apparatus from microsporidian parasites.
1. Proc Natl Acad Sci U S A - published March 1, 2025
2. Usmani M, Coudray N, Riggi M, Raghu R, Ramchandani H, Bobe D, Kopylov M, Zhong ED, Iwasa JH, Ekiert DC, Bhabha G
A sensitive and rapid visual method of chicken sexing based on LAMP-CRISPR/Cas12a system.
1. Br Poult Sci - published March 1, 2025
2. Chen Q, Su C, Li S, Zhang Z, Yang Y, Yang Y, Tao D, Xie S, Gong P, Feng Y
Amphipathic Antimicrobial Peptides Illuminate a Reciprocal Relationship between Self-assembly and Cytolytic Activity.
1. Angew Chem Int Ed Engl - published March 1, 2025
2. Laguera B, Golden MM, Wang F, Gnewou O, Tuachi A, Egelman EH, Wuest WM, Conticello VP
Mechanistic basis for PYROXD1-mediated protection of the human tRNA ligase complex against oxidative inactivation.
1. Nat Struct Mol Biol - published March 1, 2025
2. Loeff L, Kroupova A, Asanović I, Boneberg FM, Pfleiderer MM, Riermeier L, Leitner A, Ferdigg A, Ackle F, Martinez J, Jinek M
Redirecting immune signaling with cytokine adaptors.
1. Nat Commun - published March 1, 2025
2. Abhiraman GC, Householder KD, Rodriguez GE, Glassman CR, Saxton RA, Breuer CB, Wilson SC, Su L, Yen M, Hsu C, Pillarisetty VG, Reticker-Flynn NE, Garcia KC
Conformational landscapes of a class I ribonucleotide reductase complex during turnover reveal intrinsic dynamics and asymmetry.
1. Nat Commun - published March 1, 2025
2. Xu D, Thomas WC, Burnim AA, Ando N
Evolutionary adaptations of doublet microtubules in trypanosomatid parasites.
1. Science - published March 1, 2025
2. Doran MH, Niu Q, Zeng J, Beneke T, Smith J, Ren P, Fochler S, Coscia A, Höög JL, Meleppattu S, Lishko PV, Wheeler RJ, Gluenz E, Zhang R, Brown A
Genome-wide mutagenesis identifies factors involved in MRSA vaginal colonization.
1. Cell Rep - published March 1, 2025
2. Lyon LM, Marroquin SM, Thorstenson JC, Joyce LR, Fuentes EJ, Doran KS, Horswill AR
Structure of a putative terminal amidation domain in natural product biosynthesis.
1. Structure - published March 1, 2025
2. Rankin MR, Khare D, Gerwick L, Sherman DH, Gerwick WH, Smith JL
An asymmetric nautilus-like HflK/C assembly controls FtsH proteolysis of membrane proteins.
1. EMBO J - published March 1, 2025
2. Ghanbarpour A, Telusma B, Powell BM, Zhang JJ, Bolstad I, Vargas C, Keller S, Baker TA, Sauer RT, Davis JH
Structure-guided design of partial agonists at an opioid receptor.
1. Nat Commun - published March 1, 2025
2. Varga BR, Bernhard SM, El Daibani A, Zaidi SA, Lam JH, Aguilar J, Appourchaux K, Nazarova AL, Kouvelis A, Shinouchi R, Hammond HR, Eans SO, Weinreb V, Margolis EB, Fay JF, Huang XP, Pradhan A, Katritch V, McLaughlin JP, Majumdar S, Che T
Discovery, functional characterization, and structural studies of the NRPS-independent siderophore synthetases.
1. Crit Rev Biochem Mol Biol - published March 1, 2025
2. Patel KD, Fisk MB, Gulick AM
Zebrafish and cellular models of SELENON-Congenital myopathy exhibit novel embryonic and metabolic phenotypes.
1. Skelet Muscle - published March 1, 2025
2. Barraza-Flores P, Moghadaszadeh B, Lee W, Isaac B, Sun L, Hickey ET, Rockowitz S, Sliz P, Beggs AH
Comprehensive proteomics metadata and integrative web portals facilitate sharing and integration of LINCS multiomics data.
1. Mol Cell Proteomics - published March 1, 2025
2. Vidović D, Shamsaei B, Schürer SC, Kogan P, Chojnacki S, Kouril M, Medvedovic M, Niu W, Azeloglu EU, Birtwistle MR, Chen Y, Chen T, Hansen J, Hu B, Iyengar R, Jayaraman G, Li H, Liu T, Sobie EA, Xiong Y, Berberich MJ, Bradshaw G, Chung M, Everley RA, Gaudio B, Hafner M, Kalocsay M, Mills CE, Nariya MK, Sorger PK, Subramanian K, Victor C, Banuelos M, Dardov V, Holewinski R, Manalo DM, Mandefro B, Matlock AD, Ornelas L, Sareen D, Svendsen CN, Vaibhav V, Van Eyk JE, Venkatraman V, Finkbiener S, Fraenkel E, Rothstein J, Thompson L, Asiedu J, Carr SA, Christianson KE, Davison D, Dele-Oni DO, DeRuff KC, Egri SB, Jacome ASV, Jaffe JD, Lam D, Litichevskiy L, Lu X, Mullahoo J, Officer A, Papanastasiou M, Peckner R, Toder C, Blanchard J, Bula M, Ko T, Tsai LH, Young JZ, Sharma V, Pillai A, Meller J, MacCoss MJ
TOR1AIP2 as a candidate gene for dystonia-hemichorea/hemiballism.
1. Parkinsonism Relat Disord - published March 1, 2025
2. Kafantari E, Hernandez VJ, Necpál J, Leonidou M, Baureder R, Hedberg-Oldfors C, Jech R, Zech M, Schwartz TU, Puschmann A
Cardiotoxicity of breast cancer drug treatments.
1. Transl Oncol - published March 1, 2025
2. Haque M, Atallah N, Patke R, Harris AE, Woodcock CL, Varun D, Thompson RL, Jackson-Oxley J, Okui CH, Dean A, Alsaleem M, Rakha E, Irshad S, Davis MB, Jeyapalan JN, Mongan NP, Rutland CS
Blunted CD40-responsive enhancer activation in CREBBP-mutant lymphomas can be restored by enforced CD4 T-cell engagement.
1. Blood - published March 1, 2025
2. Yang H, Zhang W, Ravanmehr V, Cui G, Bowman K, Chen R, Henderson J, Lockman SR, Rojas E, Wilson AL, Parsons S, Mechaly A, Regad L, Haouz A, Flowers CR, Neelapu SS, Nastoupil LJ, Davis RE, Deng Q, Rodrigues Lima F, Green MR
Phosphate-dependent nuclear export via a non-classical NES class recognized by exportin Msn5.
1. Nat Commun - published March 1, 2025
2. Fung HYJ, Mittal SR, Niesman AB, Jiou J, Shakya B, Yoshizawa T, Cansizoglu AE, Rout MP, Chook YM
In vitro reconstitution reveals substrate selectivity of protein S-acyltransferases.
1. J Biol Chem - published March 1, 2025
2. Mondal T, Song J, Banerjee A
Precision projections of the delay of resistance mutations in non-small cell lung cancer via suppression of APOBEC.
1. Lung Cancer - published March 1, 2025
2. Nousias O, Mandell JD, Anderson KS, Townsend JP
Sustained Vaccine Exposure Elicits More Rapid, Consistent, and Broad Humoral Immune Responses to Multivalent Influenza Vaccines.
1. Adv Sci (Weinh) - published March 1, 2025
2. Saouaf OM, Ou BS, Song YE, Carter JJ, Yan J, Jons CK, Barnes CO, Appel EA
The Structural Basis of Substrate Selectivity of the Acinetobactin Biosynthetic Adenylation Domain, BasE.
1. J Biol Chem - published March 1, 2025
2. Ahmed SF, Gulick AM
Integrative Protein Assembly With LZerD and Deep Learning in CAPRI 47-55.
1. Proteins - published March 1, 2025
2. Christoffer C, Kagaya Y, Verburgt J, Terashi G, Shin WH, Jain A, Sarkar D, Aderinwale T, Maddhuri Venkata Subramaniya SR, Wang X, Zhang Z, Zhang Y, Kihara D
Mechanism of ASF1 engagement by CDAN1.
1. Nat Commun - published March 1, 2025
2. Sedor SF, Shao S
50-Fold Adjuvant and 20-Fold Antigen Vaccine Dose Sparing from Nanoliposome Display of a Stabilized Malarial Protein Antigen.
1. ACS Nano - published March 1, 2025
2. Song Y, Huang WC, Ivanochko D, Long C, Li Q, Zhou L, Julien JP, Miura K, Lovell JF
Biochemical profiling and structural basis of ADAR1-mediated RNA editing.
1. Mol Cell - published March 1, 2025
2. Deng X, Sun L, Zhang M, Basavaraj R, Wang J, Weng YL, Gao Y
An αIIbβ3 Ligand-Mimetic Murine Monoclonal Antibody That Produces Platelet Activation by Engaging the FcγIIa Receptor.
1. Blood Adv - published March 1, 2025
2. Wang J, Buitrago L, Wang L, Li J, Walz T, Coller BS
Structural basis of gap-filling DNA synthesis in the nucleosome by DNA Polymerase β.
1. Nat Commun - published March 1, 2025
2. Weaver TM, Ryan BJ, Thompson SH, Hussen AS, Spencer JJ, Xu Z, Schnicker NJ, Freudenthal BD
Molecular glues that inhibit deubiquitylase activity and inflammatory signaling.
1. Nat Struct Mol Biol - published March 1, 2025
2. Chandler F, Reddy PAN, Bhutda S, Ross RL, Datta A, Walden M, Walker K, Di Donato S, Cassel JA, Prakesch MA, Aman A, Datti A, Campbell LJ, Foglizzo M, Bell L, Stein DN, Ault JR, Al-Awar RS, Calabrese AN, Sicheri F, Del Galdo F, Salvino JM, Greenberg RA, Zeqiraj E
Author Correction: Fused radical SAM and αKG-HExxH domain proteins contain a distinct structural fold and catalyse cyclophane formation and β-hydroxylation.
1. Nat Chem - published March 1, 2025
2. Morishita Y, Ma S, De La Mora E, Li H, Chen H, Ji X, Usclat A, Amara P, Sugiyama R, Tooh YW, Gunawan G, Pérard J, Nicolet Y, Zhang Q, Morinaka BI
Author Correction: Endocytosis in the axon initial segment maintains neuronal polarity.
1. Nature - published March 1, 2025
2. Eichel K, Uenaka T, Belapurkar V, Lu R, Cheng S, Pak JS, Taylor CA, Südhof TC, Malenka R, Wernig M, Özkan E, Perrais D, Shen K
Distinct binding modes drive the broad neutralization profile of two persistent influenza hemagglutinin stem-specific antibody lineages.
1. Structure - published March 1, 2025
2. Mantus GE, Cerutti G, Chambers M, Gillespie RA, Shimberg GD, Spangler A, Gorman J, Zhou T, Shen CH, Kanekiyo M, Kwong PD, Shapiro L, Andrews SF
Rigid enlargement of sybodies with antibody fragments for cryo-EM analyses of small membrane proteins.
1. Sci Rep - published March 1, 2025
2. Ackle F, Thavarasah S, Earp JC, Seeger MA
Cryo-EM structure of the brine shrimp mitochondrial ATP synthase suggests an inactivation mechanism for the ATP synthase leak channel.
1. Cell Death Differ - published March 1, 2025
2. Kumar A, da Fonseca Rezende E Mello J, Wu Y, Morris D, Mezghani I, Smith E, Rombauts S, Bossier P, Krahn J, Sigworth FJ, Mnatsakanyan N
Genetic protection from type 1 diabetes resulting from accelerated insulin mRNA decay.
1. Cell - published March 1, 2025
2. van Tienhoven R, O'Meally D, Scott TA, Morris KV, Williams JC, Kaddis JS, Zaldumbide A, Roep BO
ICTV Virus Taxonomy Profile: Adnaviria 2025.
1. J Gen Virol - published March 1, 2025
2. Krupovic M, Wang F, Cvirkaite-Krupovic V, Kuhn JH, Dolja VV, Prangishvili D, Egelman EH, Koonin EV
Conformational and Stability Analysis of SARS-CoV-2 Spike Protein Variants by Molecular Simulation.
1. Pathogens - published March 1, 2025
2. Olivos-Ramirez GE, Cofas-Vargas LF, Madl T, Poma AB
Reconsidering "inclusive language:" Consequences for healthcare and equitableness of a growing linguistic movement to address gender identity with a path forward.
1. Sex Reprod Healthc - published March 1, 2025
2. Bartick M, Dahlen H, Gamble J, Walker S, Mathisen R, Gribble K
Facile lipid nanoparticle size engineering approach via controllable fusion induced by depletion forces.
1. J Colloid Interface Sci - published March 1, 2025
2. Wang H, Pestre H, Tan EN, Wedemann L, Schuhmacher JS, Schuhmacher M, Stellacci F
Organic anion transporting polypeptides: Pharmacology, toxicology, structure, and transport mechanisms.
1. Pharmacol Rev - published March 1, 2025
2. Hagenbuch B, Stieger B, Locher KP
Structure-guided design of a truncated heterobivalent chemical probe degrader of IRE1α.
1. RSC Med Chem - published March 1, 2025
2. Zerfas BL, Liu Y, Che J, Donovan KA, Hatcher JM, Huerta F, Metivier RJ, Nowak RP, Ragosta L, Tsang T, Fischer ES, Jones LH
Gut Microbiome-Produced Bile Acid Metabolite Lengthens Circadian Period in Host Intestinal Cells.
1. bioRxiv - published March 1, 2025
2. Powell CE, Dohnalová L, Eisert RJ, Sun ZJ, Seo HS, Dhe-Paganon S, Thaiss CA, Devlin AS
Convergent and clonotype-enriched mutations in the light chain drive affinity maturation of a public antibody.
1. bioRxiv - published March 1, 2025
2. Rao V, Sapse I, Cohn H, Yoo DK, Tong P, Clark J, Bozarth B, Chen Y, Srivastava K, Singh G, Krammer F, Simon V, Wesemann D, Bajic G, Coelho CH