Supported Applications

GFOLD

Description

(Generalized FOLD) a generalized fold change for ranking differentially expressed genes from RNA-seq data. GFOLD is especially useful when no replicate is available. GFOLD generalizes the fold change by considering the posterior distribution of log fold change, such that each gene is assigned a reliable fold change. It overcomes the shortcoming of p-value that measures the significance of whether a gene is differentially expressed under different conditions instead of measuring relative expression changes, which are more interesting in many studies. It also overcomes the shortcoming of fold change that suffers from the fact that the fold change of genes with low read count are not so reliable as that of genes with high read count, even these two genes show the same fold change.
Installation
Use the following command to install this title with the CLI client: $ biogrids-cli install gfold Available operating systems: Linux 64, OS X INTEL
Primary Citation*

J. Feng, C. A. Meyer, Q. Wang, J. S. Liu, X. S. Liu, and Y. Zhang. 2012. GFOLD: a generalized fold change for ranking differentially expressed genes from RNA-seq data. Bioinformatics. 28(21): 2782-2788.
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